The peptide consists of just three amino acids, glycine, histidine, and lysine, with an exceptionally high affinity for copper(II) ions
The whole episode is a great listen, but if you want to hear this specific discussion, check out the youtube video below: 3
Aebi H (1984) Catalase in vitro
Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium
It achieves this by stimulating the formation of new blood vessels, a process known as angiogenesis, which is crucial for delivering nutrients and oxygen to healing tissues